Lung cancer has
become the one of the major threats to world healthcare, with death rate of one
out of four deaths in both men and women. It is among one of reason of cancer related deaths all over the world
1. Golbally lung cancer accounts for
about 13 % of
new cancer cases and 19 % fatality . In India, lung cancer accounts for
6.9 % of new cases and 9.3% deaths in both sexes, it is the commonest
cancer and cause of cancer related mortality in men, and second most in women after breast and
ovarian carcinoma 2. Depending on tumour size and stages of
lung cancer several therapeutic regimens are available to treat lung cancer. Still
traditional treatments like chemotherapy and radiation therapy are associated
with several adverse effects on the human system. Even though of the progress in development of several anticancer drugs, chemoresistance
is main obstacle that results in the failure
of treatment3.
Multiple factors are involved in development of chemoresistance such as
inactivation of chemotherapy treatment, variation in tumor suppressor gene,
anti and pro apoptotic proteins. Understanding the moleculer role of tumor
encoded gene in development of drug resistance has great significance in
development of novel therapeutic target and also progress in diagnosis4.
Tissue
transglutaminase 2 (TG2) is one of
ubiquitously expressed protein among 7 members of Tissue TG family. It is known
to be involved in tumor metastasis 5. It is distributed among
major cell types and tissues and plays a significant role in several biological
processes. It take part in post-translation modification transamidase activity it is involved in
GTPase, ATPase, protein kinase, protein disulfide, and isomerase activity 6.
Up-regulated
TG2 levels leads to different
pathological disorders such as Alzheimer’s, Parkinson’s disease, multiple
sclerosis, celiac along with tumour
development while Over expression of TG2is associated with malignant effects
leading to tumorigenesis, invasion, cell differentiation, and failure in apoptosis
7.As a consequence, TG2 is known to have a significant impact in lung
carcinoma, especially towards n
on-small cell lung carcinoma 8.
Targeting TG2 protein may be valuable in identifying potential inhibitors
against lung cancer. Numerous natural compounds have been reported to have many
biological activities as antibacterial, antiviral and anti-cancer 9. Natural
products and their derivatives mimic over 50% of all the products that are
being used. In the present study an attempt is made in silico investigation of natural inhibitors against TG2 from
plant origin. The hit compounds obtained in this study could play an important
role in designing personalized therapy against lung cancer patients.
