Introduction: Epilepsy is a chronic neurological disorder, occurringdue to uncontrolled neuronal discharge. There are about 70 million cases ofepilepsy all over the world, and out of those, approximately 12 million casesare lodged in India; which is about one-sixth of the global load 1. There areover 20 anti-epileptic drugs and 2 implantable anti-epileptic devices availablecommercially in the United States 2.
This list is extensive and non-inclusiveof the extended release formulations 3, the newer vagus nerve stimulationtechnology 4, and dietary therapies modifications. Among the currently available anti-epileptic drugs(AED), conventional AEDs include Phenytoin, Phenobarbital, Carbamazepine,Valproic acid, Ethosuximide, Trimethadione and newer AEDs include Vigabatrin, Tiagabine,Gabapentin, Topiramate, Zonesamide, Lamotrigine, Felbamate, Levetiracetam,Lacosamide. 5The increasing possible treatments for epilepsy are aboon for patients. A numberof newer anti-epileptic drugs have been developed in the last few years toimprove the treatment outcomes in epilepsy.
They will provide more options toachieve a good outcome and better quality of life and can be challenging to thedoctors. Noneof the newer AEDs have been found to be better than the conventional AEDs.However, the “2004 American Academy of Neurology report” 6 suggested that newergeneration AEDs have almost same efficacy but better tolerability thanconventional drugs.Epilepsy is a social stigma 7 asepileptic patients face many psychosocial problems (like anxiety, difficulty indriving, unemployment) that can deteriorate the HR-QOL. Increasing awarenessabout it has led to the need to quantify HR-QOL in epileptic patients.
So,appropriate AED use, along with monitoring of adverse effects, and assessmentof HR-QOL as an outcome measure are important in the management of epilepsy.Demographic characters, seizure frequency,and extended period of the disease are related with poor HR-QOL 8. There are lesser studies examining theimpact of AED pharmacotherapy on HR-QOL 9.
Keeping this rationale in mind we decidedto go for this particular research study which will not only inform usregarding the AEDs prescribed conventional or newer, and will give us abaseline data on the quality of life in such patients.