Food shock). It doesn’t mean that if one has

Food allergy reaction occurs when our immune responses overreact to a food or a substance in a food, identifying it as a danger and triggering a protective response Food allergy (FA), defined as an immunoglobulin (Ig) E-mediated hypersensitivity reaction to food, is emerging as a major clinical and public health problem worldwide. The manifestation of allergic diseases varies throughout life such as food allergy and eczema mostly develop in infants, asthma in young children, and rhinitis in older children and adults’ Allergic diseases are caused by the activation of mast cells and basophils through cell-surface-bound IgE. This causes the release of histamine and other mediators, leading to allergic inflammation.Hypersensitive responses to food allergic reaction can range from minor to severe (anaphylactic shock). It doesn’t mean that if one has experienced a minor allergic reaction to food allergen then he or she can’t have a severe reaction to the same allergen in the later stage of life. It’s all about a matter of allergen quantity and exposure route. Regardless of this advances in research and technology our understanding of increasing food allergy evidence is quite low, even we don’t have adequate knowledge about biological mechanistic of food allergy. Like other allergic diseases, food allergy is also determined by genetic and environmental interaction. The use of gene informatics, by the sequencing of the human genome, has started new gears and skills which raised up widespread hope for Food allergy genetics. This food allergen informatics can also significantly contribute to the prediction, prevention, and treatment of Food allergy. While allergies tend to run in families, it is impossible to predict whether a child will inherit a parent’s food allergy or whether siblings will have a similar condition. Earlier studies showed that it may be possible that if the elder sibling of a child is sensitive to any food allergen will also have chances to be allergic to the same allergen. individuals allergic to a specific food may also possibly have allergic reactions to related foods and food product, like a person have an allergy for chicken egg may also show allergic responses to the egg from other birds. The risk factors associated with food allergy include genetics, age, family history (specifically an allergic family background).Genetics of atopy and allergy have already revealed a number of the genetic marker which known for making people susceptible to a different food allergen. Several studies provide strong evidence that host genetic susceptibility and environmental factors determine the complex regulation of IgE-mediated food allergies. Researchers have soughed for identifying an association between variants such as single nucleotide polymorphisms (SNPs) in the main pathways that influence allergic diseases pathogenesis. Single Nucleotide Polymorphisms (SNPs) are associated with the development of a certain food allergy phenotype.We will focus on four candidate genes, interleukin-4 (IL-4), IL-4 receptor a-chain (IL-4Ra)), and signal transducer and activator of transcription 6 (STAT-6), for enhancement of IgE production and action. Furthermore, we will also be analyzing IL-10, which has been reported as a regulatory cytokine that controls the balance between Th1/Th2. We have selected these four SNPs (single SNP per one gene) to be functionally important and which is associated with atopy or allergy. Correlation with the severity of allergic diseases will be speculated to be much stronger with a combined analysis of a series of proteins for IgE production than single gene analysis.Previous studies determined that IL-4 regulates susceptibility to intestinal inflammation in murine food allergy. The mechanism underlying the initiation and development of allergic responses involves IL-4 that directly induces the differentiation of committed effector Th2 lymphocytes. Polymorphism in IL-4 (C590T) has been forecast associated with asthma and atopy in Japanese and US populations. IL-4 acts by binding to its receptor on target cells, which is a heterodimer of 140 kD IL-4 receptor ? (IL-4R?). At least eight SNP has been documented with (IL-4R?) of which result in protein exchanges in the mature protein. The (A1652G) allele of IL-4R? have found to be associated with atopy in Caucasians. The polymorphism associated with IL-4 and IL-4R? genes also play important role in autoimmune diseases and some infectious diseases such as respiratory syncytial virus (RSV) bronchiolitis and human immunodeficiency virus (HIV) type 1 disease. The STAT6 located on chromosome 12q13.3–14·1 just within the inflammatory bowel disease(IBD2) locus, as defined by recent genome-wide linkage studies. STAT6 is a key transcription factor involved in interleukin 4 (IL-4) and IL-13-mediated Th2 response. Some common STAT6(G2964A) SNP are known to be associated with food allergy and asthma predisposition and/or IgE levels. Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine that can down-regulate cellular immunity and allergic inflammation. Several important polymorphic sites in the IL-10 gene have been reported, a case-control association study suggested that the IL-10 (C627A) gene polymorphism is related to food allergy susceptibility in atopic Japanese children.Even though several genetic studies have analysed single nucleotide polymorphisms (SNPs) as risk factors for food allergic, the aim of our research is to study the correlation between SNPs of four genes and that may lead food allergy in North Indian population. We will use a questionnaire and clinical recordings to analyse the effect of environmental factors.


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