Background frequent systemic reaction in apheresis occurs as a

Background Information and justification Platelet apheresis is a method of collecting platelets performed by a device which separate platelets and return the rest of blood to the donor in a safe manner. The donor should be connected to the apheresis machine through the sterile tubing system with the help of a large bore needle.  After removing blood from the donor using a large bore needle, a measured amount of anticoagulant (Citrate) is mixed to prevent the coagulation. Then it is transferred to the place where the separation is taken place, either the centrifugation bowl, chamber or belt. The same principle is applied in apheresis as for the blood component preparation by the whole blood. Based on specific gravity and the weight of the constituents’ separation of blood components is done.
While the platelets are diverted to the temporary storage remaining
elements are returned to the donor by an intermittent or continuous
flow. (Modern332) as the Although platelet aphaeresis procedures are
well tolerated than whole blood donations significant level of adverse events (AEs) occur during and after the procedure. Those AEs can be severe in apheresis procedures but are less often with the comparison to the whole blood donations. AEs to apheresis procedures can be categorized as systemic or local. Citrate toxicity is known to be the most frequent systemic reaction in apheresis occurs as a result of the anticoagulant acid-citrate-dextrose. Chelation of calcium ions by citrate causes hypocalcemia which can
be presented as per oral tingling and paraesthesia, chills, nausea,
twitching, tremors or severe symptoms like carpopedal spasms, seizures,
tetany and cardiac arrhythmias. The vasovagal reaction can be triggered
by the anxiety and tension for the undergoing procedure or due
to the pain caused by the venepuncture. It is characterized by the
pallor, sweating, dizziness, nausea, hypotension, and syncope.   Local
reactions include hematomas, bruising and phlebitis as a result of
defective venepuncture and irritation or allergy to needles.  Adverse
effects due to platelet apheresis are mostly under-reported. This is mainly due to the high tolerance of the regular
platelet apheresis donors. Being most frequent adverse effect of
platelet apheresis citrate toxicity is highly under-reported as the mild symptoms such as perioral tingling and paresthesia are well
tolerated and not complained by the donors. Therefore addressing and
reporting of each and every adverse event lies a greater importance in
ensuring the donor safety and stabilizing the donor pool. No study has
yet been carried out in Sri Lanka in relevant to adverse effects in
platelet apheresis. The scarcity of studies done elsewhere in the world,
demands more research as to improve the donor safety and to promote apheresis procedures. Objectives General Objective   Specific objectives ·         To assess the frequency of adverse events
due to platelet apheresis donations ·         To evaluate donor
variables as potential risk factors for different types adverse events
(AEs) during apheresis collections ·         To assess the knowledge and attitude on adverse effects of apheresis procedures in platelet apheresis donors ·         To identify the frequency of underreported adverse events as a result of the tolerance by the donors


I'm Neil!

Would you like to get a custom essay? How about receiving a customized one?

Check it out